Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Ji‐chun Zhang; Jin Wu; Yūkō Fujita; Wei Yao; Qian Ren

doi:10.1093/ijnp/pyu077

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Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Ji‐chun Zhang, Jin Wu, Yūkō Fujita, Wei Yao, Qian Ren, Chun Yang, Su‐Xia Li, Yukihiko Shirayama, Kenji Hashimoto

University of Oxford (2015) • Volume 18, Issue 4

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Abstract

The results suggest that LPS-induced inflammation may cause depression-like behavior by altering BDNF and spine density in the CA3, DG, PFC, and NAc, which may be involved in the antidepressant effects of 7,8-DHF and ANA-12, respectively.

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Publication Info

DOI

10.1093/ijnp/pyu077

Language

English

Topic

Tryptophan and brain disorders

Keywords

Tropomyosin receptor kinase B, Brain-derived neurotrophic factor, Antidepressant, Internal medicine, Endocrinology, Nucleus accumbens, Neurotrophic factors, Behavioural despair test, Prefrontal cortex, Pharmacology, Hippocampus, Chemistry, Medicine, Psychology, Receptor, Neuroscience

Published

January 26, 2015

Citations

282 citations

FWCI

13.43

External Resources

DOI Link OpenAlex

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Abstract

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Publication Info

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