Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

Nicholas I. Fleming; Kevin C. Knower; Kyren A. Lazarus; Peter J. Fuller; Evan R. Simpson

doi:10.1371/journal.pone.0014389

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Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

Nicholas I. Fleming, Kevin C. Knower, Kyren A. Lazarus, Peter J. Fuller, Evan R. Simpson, Colin D. Clyne

Public Library of Science (2010) • Volume 5, Issue 12, Pages e14389-e14389

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Abstract

These findings suggest that aromatase is a direct target of FOXL2:C134W in adult-type GCT via a single distinctive and highly conserved binding site in PII and therefore provide insight into the pathogenic mechanism of this mutation.

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Publication Info

DOI

10.1371/journal.pone.0014389

Language

English

Topic

FOXO transcription factor regulation

Keywords

Aromatase, Steroidogenic factor 1, Biology, Granulosa cell, Mutation, Promoter, Luciferase, Molecular biology, Electrophoretic mobility shift assay, Transcription factor, Cell biology, Gene, Cancer research, Gene expression, Ovary, Genetics, Nuclear receptor, Transfection, Cancer

Published

December 20, 2010

Citations

139 citations

FWCI

4.33

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DOI Link OpenAlex

Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

Abstract

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Publication Info

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