CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

David Gallo; Jordan T.F. Young; Jimmy Fourtounis; Giovanni Martino; Alejandro Álvarez-Quilón

doi:10.1038/s41586-022-04638-9

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

David Gallo, Jordan T.F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin...

Nature Portfolio (2022) • Volume 604, Issue 7907, Pages 749-756

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Publication Info

DOI

10.1038/s41586-022-04638-9

Language

English

Topic

Cancer Genomics and Diagnostics

Keywords

Cyclin E1, Cancer research, Biology, Synthetic lethality, Olaparib, Cell cycle, Cell, Cyclin, Genetics, DNA repair, DNA, Poly ADP ribose polymerase

Published

April 20, 2022

Citations

184 citations

FWCI

25.15

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CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

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Publication Info

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