CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Sarah L. Clarke; Gareth J. Betts; Andrea Plant; Kate Wright; Tariq El‐Shanawany

doi:10.1371/journal.pone.0000129

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Sarah L. Clarke, Gareth J. Betts, Andrea Plant, Kate Wright, Tariq El‐Shanawany, Richard Harrop, Jared Torkington, B I Rees, Geraint T. Williams, Awen Gallimore, Andrew Godkin

Public Library of Science (2006) • Volume 1, Issue 1, Pages e129-e129

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Abstract

Collectively, these data demonstrate that Treg capable of inhibiting tumor associated antigen-specific immune responses are enriched in patients with CRC. These results support a rationale for manipulating Treg to enhance cancer immunotherapy.

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Publication Info

DOI

10.1371/journal.pone.0000129

Language

English

Topic

Immune Cell Function and Interaction

Keywords

FOXP3, Immune system, IL-2 receptor, Medicine, Regulatory T cell, Colorectal cancer, Immunology, Antigen, Peripheral blood mononuclear cell, Immunotherapy, T cell, Flow cytometry, Cancer research, Cancer, Immune tolerance, Internal medicine, Biology

Published

December 26, 2006

Citations

216 citations

FWCI

6.23

External Resources

DOI Link OpenAlex

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Abstract

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Publication Info

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