The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

Fiona Thistlethwaite; David E. Gilham; Ryan D. Guest; Dominic G. Rothwell; Manon Pillai

doi:10.1007/s00262-017-2034-7

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

Fiona Thistlethwaite, David E. Gilham, Ryan D. Guest, Dominic G. Rothwell, Manon Pillai, Deborah J. Burt, Andrea J. Byatte, Н. А. Кириллова, Juan W. Valle, Surinder K. Sharma, Kerry Chester, Nigel Westwood, Sarah Halford, Stephen Nabarro, Susan Wan...

Springer Science+Business Media (2017) • Volume 66, Issue 11, Pages 1425-1436

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Publication Info

DOI

10.1007/s00262-017-2034-7

Language

English

Topic

CAR-T cell therapy research

Keywords

Carcinoembryonic antigen, Persistence (discontinuity), Medicine, Conditioning, Transient (computer programming), Immunology, Immunotherapy, Toxicity, Respiratory system, Internal medicine, Immune system, Computer science

Published

June 28, 2017

Citations

389 citations

FWCI

16.99

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The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

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