Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents: a systematic review of randomized controlled trials

Roberto Lorenzetti; Angelo Zullo; Lorenzo Ridola; Andrea Picchianti Diamanti; Bruno Laganà

doi:10.3109/07853890.2014.941919

Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents: a systematic review of randomized controlled trials

Roberto Lorenzetti, Angelo Zullo, Lorenzo Ridola, Andrea Picchianti Diamanti, Bruno Laganà, Luigi Gatta, Alberto Migliore, Alessandro Armuzzi, Cesare Hassan, Vincenzo Bruzzese

Informa (2014) • Volume 46, Issue 7, Pages 547-554

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Abstract

TB risk with anti-TNF agents appeared to be increased when these agents were used in combination with methotrexate or azathioprine as compared with monotherapy regimen. TB risk seemed to be higher than placebo, even when monotherapy is prescribed.

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Publication Info

DOI

10.3109/07853890.2014.941919

Language

English

Topic

Tuberculosis Research and Epidemiology

Keywords

Medicine, Tuberculosis, Tumor necrosis factor alpha, Concomitant, Risk factor, Immunology, Randomized controlled trial, Tumor necrosis factor α, Adalimumab, Internal medicine, Pathology

Published

August 8, 2014

Citations

117 citations

FWCI

5.08

External Resources

DOI Link OpenAlex

Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents: a systematic review of randomized controlled trials

Abstract

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Publication Info

External Resources

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