Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

Lenora Higginbotham; Lingyan Ping; Eric B. Dammer; Duc M. Duong; Maotian Zhou

doi:10.1126/sciadv.aaz9360

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

Lenora Higginbotham, Lingyan Ping, Eric B. Dammer, Duc M. Duong, Maotian Zhou, Marla Gearing, Cheyenne Hurst, Jonathan D. Glass, Stewart A. Factor, Erik C. B. Johnson, Ihab Hajjar, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

American Association for the Advancement of Science (2020) • Volume 6, Issue 43

PDF Available

Abstract

Integrative proteomic analysis identifies CSF biomarker panels linked to brain-based pathophysiologies in Alzheimer’s disease.

Quick Actions

Read Full Paper

Publication Info

DOI

10.1126/sciadv.aaz9360

Language

English

Topic

Alzheimer's disease research and treatments

Keywords

Cerebrospinal fluid, Proteome, Proteomics, Biomarker, Pathophysiology, Medicine, Asymptomatic, Multiplex, Disease, Biomarker discovery, Alzheimer's disease, Neuroscience, Pathology, Bioinformatics, Biology, Gene

Published

October 21, 2020

Citations

364 citations

FWCI

30.77

External Resources

DOI Link OpenAlex

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

Abstract

Quick Actions

Publication Info

External Resources

Suggested Papers

Towards conversational diagnostic artificial intelligence

Students’ voices on generative AI: perceptions, benefits, and challenges in higher education

Evaluation of PCR for diagnosis of visceral leishmaniasis

Suggested Papers

Suggested Papers

Towards conversational diagnostic artificial intelligence

Students’ voices on generative AI: perceptions, benefits, and challenges in higher education

Evaluation of PCR for diagnosis of visceral leishmaniasis