Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

Takaya Nagasaki; Masayasu Hara; Hayao Nakanishi; Hiroki Takahashi; Mikinori Sato

doi:10.1038/bjc.2013.748

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Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

Takaya Nagasaki, Masayasu Hara, Hayao Nakanishi, Hiroki Takahashi, Mikinori Sato, H Takeyama

Springer Nature (2013) • Volume 110, Issue 2, Pages 469-478

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Abstract

Cancer stromal fibroblasts were an important source of IL-6 in colon cancer. IL-6 produced by activated fibroblasts induced tumour angiogenesis by stimulating adjacent stromal fibroblasts. The relationship between IL-6 and stromal fibroblasts offers new approaches to cancer therapy.

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Publication Info

DOI

10.1038/bjc.2013.748

Language

English

Topic

Cytokine Signaling Pathways and Interactions

Keywords

Stromal cell, Angiogenesis, Cancer research, Cancer-Associated Fibroblasts, Cancer, Colorectal cancer, Cancer cell, Fibroblast, Antibody, Medicine, Biology, Immunology, Pathology, Cell culture, Internal medicine

Published

December 17, 2013

Citations

379 citations

FWCI

11.54

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DOI Link OpenAlex

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

Abstract

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Publication Info

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