Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Shama D. Ahuja; David Ashkin; Monika Avendano; Rita Banerjee; Melissa Bauer

doi:10.1371/journal.pmed.1001300

Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Shama D. Ahuja, David Ashkin, Monika Avendano, Rita Banerjee, Melissa Bauer, J Bayona, Mercedes C. Becerra, Andrea Benedetti, Marcos Burgos, Rosella Centis, Eward D. Chan, Chen‐Yuan Chiang, Helen Cox, Lia D’Ambrosio, Kathryn DeRiemer...

Public Library of Science (2012) • Volume 9, Issue 8, Pages e1001300-e1001300

PDF Available

Abstract

In this individual patient data meta-analysis of observational data, improved MDR-TB treatment success and survival were associated with use of certain fluoroquinolones, ethionamide, or prothionamide, and greater total number of effective drugs. However, randomized trials are urgently needed to optimize MDR-TB treatment. Please see later in the article for the Editors' Summary.

Quick Actions

Read Full Paper

Publication Info

DOI

10.1371/journal.pmed.1001300

Language

English

Topic

Tuberculosis Research and Epidemiology

Keywords

Medicine, Ethionamide, Odds ratio, Tuberculosis, Internal medicine, Ofloxacin, Observational study, Meta-analysis, Extensively drug-resistant tuberculosis, Intensive care medicine, Mycobacterium tuberculosis, Antibiotics, Pathology, Ciprofloxacin

Published

August 28, 2012

Citations

527 citations

FWCI

31.54

External Resources

DOI Link OpenAlex

Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Abstract

Quick Actions

Publication Info

External Resources

Suggested Papers

European guideline for the diagnosis and treatment of insomnia

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022

Radiation-Induced Skin Injuries to Patients: What the Interventional Radiologist Needs to Know

Suggested Papers

Suggested Papers

European guideline for the diagnosis and treatment of insomnia

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022

Radiation-Induced Skin Injuries to Patients: What the Interventional Radiologist Needs to Know