Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

Weihong Yin; Jong‐In Park; Richard F. Loeser

doi:10.1074/jbc.m109.056838

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Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

Weihong Yin, Jong‐In Park, Richard F. Loeser

Elsevier BV (2009) • Volume 284, Issue 46, Pages 31972-31981

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DOI

10.1074/jbc.m109.056838

Language

English

Topic

Osteoarthritis Treatment and Mechanisms

Keywords

Protein kinase B, Phosphorylation, MAPK/ERK pathway, Chemistry, PI3K/AKT/mTOR pathway, Proteoglycan, Chondrocyte, Kinase, Cell biology, Signal transduction, Internal medicine, Endocrinology, Biochemistry, Biology, Medicine, Extracellular matrix

Published

September 18, 2009

Citations

178 citations

FWCI

8.16

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Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

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Publication Info

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