Redox regulation: mechanisms, biology and therapeutic targets in diseases

Bowen Li; Hui Ming; Siyuan Qin; Edouard C. Nice; Jingsi Dong

doi:10.1038/s41392-024-02095-6

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Redox regulation: mechanisms, biology and therapeutic targets in diseases

Bowen Li, Hui Ming, Siyuan Qin, Edouard C. Nice, Jingsi Dong, Zhongyan Du, Canhua Huang

Springer Nature (2025) • Volume 10, Issue 1, Pages 72-72

SynthesisNarrativeReviewPDF AvailableGrade Eligible

Overall Assessment

Limited Methodological Quality

Assessment created by PaperScorers Medical AI v0.1.0 on Jan 15, 2026

D+

53/100

Key Takeaways

•Comprehensive narrative on redox mechanisms across genome, epigenetics, proteostasis, metabolism, and microenvironment.
•Therapeutic section contrasts antioxidants vs targeted cysteine-directed inhibitors; lists ongoing trials.
•Calls for context-specific, targetable redox sensors; small-molecule cysteine covalency highlighted.

Conclusion

Useful integrative synthesis with clear therapeutic framing; non-systematic methods limit rigor but significance is high.

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Quality Dimensions

Bias & Integrity

COI handling, outcome switching, selective reporting

B-70

Methods Rigour

Protocol clarity, sampling, controls

D-35

External Validity

Generalisability, setting, population

C60

Transparency & Reproducibility

Data/code/materials availability, preregistration

D40

Significance & Novelty

Contribution vs prior art; context if known

B75

Statistical Validity

Models, assumptions, multiplicity, CI priority

F20

Integrity & Transparency

Integrity checks

P-hacking risk?

?

None suspected

Signs of selective hypothesis testing or analysis choices that could inflate false positive rates.

Outcome switching?

?

None suspected

Evidence that primary outcomes were changed during or after the study, potentially distorting results.

Conflict of interest?

?

None suspected

Authors have financial or other relationships that could bias research findings.

Data integrity issues?

?

None suspected

Concerns about the accuracy, completeness, or authenticity of the reported data.

Open science signals

Research data

?

Not applicable

Raw data used in the analyses is publicly available or accessible upon request.

Analysis code

?

Not applicable

Code or scripts used to analyze the data are shared for reproducibility.

Study materials

?

Not applicable

Protocols, questionnaires, and other materials are publicly available.

Premise

Primary Research Question

How redox signalling regulates disease and how to exploit it therapeutically.

Hypothesis is Falsifiable

—Not specified

Review does not test a specific hypothesis.

PICO Framework

Population—Not specified

No primary participants.

Intervention—Not specified

Narrative on diverse modalities.

Comparison—Not specified

No comparator; not a trial.

Outcome—Not specified

No predefined outcomes.

Literature Positioning

Literature Review Balanced

Well covered

Broad coverage from mechanisms to trials; extensive refs and tables.

Evidence: Table 1 p. 16; Table 2 p. 17-18

Research Gap Clearly Stated

Well covered

States need for precise, context-specific redox targeting and trials.

Evidence: p. 1–3, INTRODUCTION

Stated Contribution Clear

Well covered

Summarises mechanisms and therapeutic targets; clinical progress overview.

Evidence: p. 1 Abstract; p. 3 last para

Study Provenance

Peer review unclearGrant funding disclosedConflicts disclosedAffiliations listed

Authors & Affiliations

Multiple institutions in China and Australia listed on title page.

Funding Statement

Supported by Chinese national grants and West China Hospital 1·3·5 project (p. 29 ACKNOWLEDGEMENTS).

Conflicts of Interest

One author is journal editorial board; not involved in handling; others no COI (p. 29).

Peer Review

?Nature journal implies peer review; not stated explicitly in text.

Evidence: p. 1

Methodological Assessment

All design modules are marked as not applicable. Use the accordion below to review their details.

Modules without applicable checklist items (10)

These designs were fully marked as not applicable but remain available for reference.

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Study Overview

Study Design

Narrative Review

Primary classification used to evaluate this research.

Population

Not a primary study; narrative review across diseases and mechanisms.

Brief summary of who or what was studied.

Pre-registration

Not registered

Indicates whether the protocol or trial was registered before data collection.

Reviewer Notes

Narrative review integrating redox biology and clinical targets; non-systematic.

Publication Details

DOI

10.1038/s41392-024-02095-6

Published

March 7, 2025

Citations

101 citations

FWCI

464.74

External Resources

DOI Link OpenAlex

Disclaimer: This assessment is generated by AI and should not be the sole basis for clinical or research decisions. Always review the original paper and consult with domain experts.

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