Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

Silvia Ling; Edwin Lau; Ammira Al-Shabeeb; Aleksandra Nikolić; Alberto Catalano

doi:10.3324/haematol.2011.043331

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

Silvia Ling, Edwin Lau, Ammira Al-Shabeeb, Aleksandra Nikolić, Alberto Catalano, Harry Iland, Noemi Horvath, P. Joy Ho, Simon J. Harrison, Shaun Fleming, D. Joshua, John Allen

Ferrata Storti Foundation (2011) • Volume 97, Issue 1, Pages 64-72

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Abstract

The unfolded protein response may be a relevant target pathway for proteasome inhibitors in the treatment of myeloma and its regulator XBP-1 is a potential response marker. (The BIR study was registered with Australian Clinical Trial Registry Number 12605000770662).

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Publication Info

DOI

10.3324/haematol.2011.043331

Language

English

Topic

Ubiquitin and proteasome pathways

Keywords

Regulator, Bortezomib, Proteasome, Unfolded protein response, Proteasome inhibitor, Chemistry, Multiple myeloma, Cancer research, Cell biology, Internal medicine, Medicine, Biochemistry, Biology, Endoplasmic reticulum, Gene

Published

October 11, 2011

Citations

125 citations

FWCI

3.49

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DOI Link OpenAlex

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1

Abstract

Quick Actions

Publication Info

External Resources

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