The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells

Zhimei Lv; Qun Wang; Qiang Wan; Jiangong Lin; Mengsi Hu

doi:10.1371/journal.pone.0022806

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The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells

Zhimei Lv, Qun Wang, Qiang Wan, Jiangong Lin, Mengsi Hu, You-Xia Liu, Rong Wang

Public Library of Science (2011) • Volume 6, Issue 7, Pages e22806-e22806

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Abstract

This study suggests that p38 MAPK may play an important role in the high glucose-induced EMT by activating AP-1 in tubular epithelial cells.

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Publication Info

DOI

10.1371/journal.pone.0022806

Language

English

Topic

Chronic Kidney Disease and Diabetes

Keywords

Epithelial–mesenchymal transition, Cell biology, Mesenchymal stem cell, Chemistry, Epithelium, MAPK/ERK pathway, Signal transduction, Biology, Transition (genetics), Biochemistry

Published

July 29, 2011

Citations

111 citations

FWCI

5.53

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The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells

Abstract

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Publication Info

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