The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

Deepak Adhikari; Nagaraju Gorre; Sanjiv Risal; Zhiyi Zhao; Hua Zhang

doi:10.1371/journal.pone.0039034

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The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

Deepak Adhikari, Nagaraju Gorre, Sanjiv Risal, Zhiyi Zhao, Hua Zhang, Yan Shen, Kui Liu

Public Library of Science (2012) • Volume 7, Issue 6, Pages e39034-e39034

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Abstract

Long-term monitoring up to the second generation of progeny mice showed that the mice were reproductively active and were free from any overt signs or symptoms of chronic illnesses. Our results indicate that the use of PTEN inhibitors could be a safe and effective way of generating mature human oocytes for use in novel IVF techniques.

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Publication Info

DOI

10.1371/journal.pone.0039034

Language

English

Topic

Reproductive Biology and Fertility

Keywords

PTEN, Tensin, Biology, Folliculogenesis, Ovarian follicle, Ovary, Follicular phase, Internal medicine, Follicle, Premature ovarian failure, Gonadotropin, Endocrinology, Andrology, PI3K/AKT/mTOR pathway, Cancer research, Cell biology, Embryo, Embryogenesis, Signal transduction, Hormone, Medicine

Published

June 27, 2012

Citations

104 citations

FWCI

10.36

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The Safe Use of a PTEN Inhibitor for the Activation of Dormant Mouse Primordial Follicles and Generation of Fertilizable Eggs

Abstract

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