Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Maria V. Babak; Samuel M. Meier; K. Huber; Jóhannes Reynisson; Anton A. Legin

doi:10.1039/c4sc03905j

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Maria V. Babak, Samuel M. Meier, K. Huber, Jóhannes Reynisson, Anton A. Legin, Michael A. Jakupec, Alexander Roller, Alexey Stukalov, Manuela Gridling, Keiryn L. Bennett, Jacques Colinge, Walter Berger, Paul J. Dyson, Giulio Superti‐Furga, Bernhard K. Keppler...

Royal Society of Chemistry (2015) • Volume 6, Issue 4, Pages 2449-2456

PDF Available

Abstract

The RAPTA pharmacophore was linked to beads to identify its biomolecular targets in cancer cells.

Quick Actions

Read Full Paper

Publication Info

DOI

10.1039/c4sc03905j

Language

English

Topic

Metal complexes synthesis and properties

Keywords

Mode of action, Profiling (computer programming), Relevance (law), Proteomics, Chemistry, Computational biology, Combinatorial chemistry, Computer science, Biology, Biochemistry, Political science

Published

January 1, 2015

Citations

141 citations

FWCI

9.32

External Resources

DOI Link OpenAlex

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Abstract

Quick Actions

Publication Info

External Resources

Suggested Papers

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

A foundation model for clinical-grade computational pathology and rare cancers detection

Thoracic and cardiovascular surgery in Japan during 2014

Suggested Papers

Suggested Papers

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

A foundation model for clinical-grade computational pathology and rare cancers detection

Thoracic and cardiovascular surgery in Japan during 2014