Chimeric antigen receptor signaling: Functional consequences and design implications

Silke E. Lindner; Shereé M. Johnson; Christine E. Brown; Leo D. Wang

doi:10.1126/sciadv.aaz3223

Home SearchPaper Details

Chimeric antigen receptor signaling: Functional consequences and design implications

Silke E. Lindner, Shereé M. Johnson, Christine E. Brown, Leo D. Wang

American Association for the Advancement of Science (2020) • Volume 6, Issue 21, Pages eaaz3223-eaaz3223

PDF Available

Abstract

CAR signaling may incorporate emergent properties not accurately modeled by TCR signaling frameworks.

Quick Actions

Read Full Paper

Publication Info

DOI

10.1126/sciadv.aaz3223

Language

English

Topic

CAR-T cell therapy research

Keywords

Chimeric antigen receptor, T-cell receptor, Signal transduction, T cell, Receptor, Biology, Antigen, Immunology, Cell biology, Computational biology, Neuroscience, Genetics, Immune system

Published

May 20, 2020

Citations

157 citations

FWCI

9.76

External Resources

DOI Link OpenAlex

Chimeric antigen receptor signaling: Functional consequences and design implications

Abstract

Quick Actions

Publication Info

External Resources

Suggested Papers

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022

Integrating gender-based violence first-line response into family planning and antenatal care services: an assessment of feasibility, appropriateness and acceptability to healthcare providers in Sokoto and Ebonyi States, Nigeria

The Effects of Influenza Vaccination of Health Care Workers in Nursing Homes: Insights from a Mathematical Model

Suggested Papers

Suggested Papers

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022

Integrating gender-based violence first-line response into family planning and antenatal care services: an assessment of feasibility, appropriateness and acceptability to healthcare providers in Sokoto and Ebonyi States, Nigeria

The Effects of Influenza Vaccination of Health Care Workers in Nursing Homes: Insights from a Mathematical Model